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Reversan
- CBLC4H10
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H27N5O2
- MW: 441.52
Description
Reversan is a potent, selective and non-toxic multidrug resistance-associated protein (MRP1) inhibitor. Reversan gives a 3.8, 14.6 and 11.6 fold sensitization of MCF7/VP cells to the MRP1 substrates doxorubicin, vincristine and etoposide, respectively. May be clinically useful in the treatment of neuroblastoma and other cancers associated with aberrant MRP1/Pgp expression. MRP1 reversal agent.
More Information
| Parent CAS No. | 313397-13-6 |
|---|---|
| Chemical Name | N-(3-Morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide |
| SMILES | C12=C(C(=O)NCCCN3CCOCC3)C=NN1C(C1=CC=CC=C1)=CC(C1=CC=CC=C1)=N2 |
| MFCD | MFCD01528184 |
| InChi | InChI=1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32) |
| InChiKey | JTRXWCLQFAZHGP-UHFFFAOYSA-N |
| CID | 2298706 |
| Short Description | MRP1 inhibitor |
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