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DCLK1-IN-1
- FMF-03-146-1
Axon 3200
CAS:
2222635-15-4
Purity:
98%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H28F3N7O2
- MW: 527.54
Description
DCLK1-IN-1 is a potent, selective and orally bioavailable DCLK1/2 inhibitor. DCLK1-IN-1 exhibits binding assay IC50 values of 9.5 nM and 31 nM for DCLK1 and DLCK2, respectively. Moreover, DCLK1-IN-1 exhibits kinase assay IC50 values of 57.2 nM and 103 nM for DCLK1 and DLCK2, respectively.
More Information
| Parent CAS No. | 2222635-15-4 |
|---|---|
| Chemical Name | 2-(2-Methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5-(2,2,2-trifluoroethyl)-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one |
| SMILES | C12N=C(NC3C(OC)=CC(N4CCN(C)CC4)=CC=3)N=CC=1N(CC(F)(F)F)C(=O)C1C=CC=CC=1N2C |
| MFCD | N.A. |
| InChi | InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27,28)29/h4-9,14-15H,10-13,16H2,1-3H3,(H,30,31,32) |
| InChiKey | OQFCHSFVWSLDAO-UHFFFAOYSA-N |
| CID | 134457640 |
| Short Description | DCLK1/2 inhibitor |
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