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ML348
- Soluble in DMSO
- MF: C18H17ClF3N3O3
- MW: 415.79
Description
Selective and in vivo active inhibitor for acyl-protein thioesterase APT1 (IC50 values 0.84 µM and >10 µM for APT1 and APT2, respectively; Ki values 280 nM and >10000 nM for WT APT1 and APT2, respectively). A useful tool to study LYPLA/APT mediated protein S-palmitoylation and related pharmacology. In some of the literature, APT1 and APT2 are also identified as lysophospholipases LYPLA1 and LYPLA2 as they were first discovered due to their ability to hydrolyze various lysophospholipids.
More Information
| Parent CAS No. | 899713-86-1 |
|---|---|
| Chemical Name | N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide |
| SMILES | N1(CC(NC2=CC(C(F)(F)F)=CC=C2Cl)=O)CCN(C(C2=CC=CO2)=O)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26) |
| InChiKey | OXKNHBBDOIMFFQ-UHFFFAOYSA-N |
| CID | 3238952 |
| Short Description | APT1 inhibitor |
References
- I Vujic et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.
- JJ Hulce et al. An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): NCBI (US); 2010-2013 Dec 09
- SJ Won et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Oct 31.
- A Adibekian et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc. 2012 Jun 27;134(25):10345-8.
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