Bulk Inquiry
GANT61
- NSC 136476
- Soluble in DMSO and EtOH
- MF: C27H35N5
- MW: 429.6
Description
Small molecule capable of reducing GLI-mediated transcription and endogenous Hedgehog (Hh) signaling (IC50 value ca 5 µM). In vivo, GANT61 suppressed human tumor cell growth until no tumor was palpable.
More Information
| Parent CAS No. | 500579-04-4 |
|---|---|
| Chemical Name | 2,2'-(2-(pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline) |
| SMILES | C1(C2C=CN=CC=2)N(CC2=CC=CC=C2N(C)C)CCCN1CC1=CC=CC=C1N(C)C |
| MFCD | N.A. |
| InChi | InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3 |
| InChiKey | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
| CID | 421610 |
| Short Description | GLI inhibitor |
References
- M Lauth et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.
- BZ Stanton et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.
- R Zhang et al. Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. Oncotarget. 2016 Dec 6;7(49):80190-80207.
- D Pan et al. Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin. Leuk Res. 2012 Jun;36(6):742-8.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1500 | GDC 0449 |
From $77.00 |
| 1619 | NVP-LDE225 |
From $93.50 |
| 1690 | Purmorphamine |
From $132.00 |
| 2035 | RU-SKI 43 hydrochloride |
From $121.00 |
| 2196 | LY 2940680 |
From $132.00 |
| 2356 | BMS 833923 |
From $82.50 |
| 2654 | JK184 |
From $88.00 |
| 2673 | RUSKI-201 dihydrochloride |
From $148.50 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.