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ABT-089 dihydrochloride
- Pozanicline dihydrochloride
- Parent CAS: 161417-03-4
- Soluble in water and DMSO
- MF: C11H16N2O·2HCl
- MW: 265.18
Description
ABT-089 dihydrochloride (Pozanicline) is a potent, selective and orally bioavailable nicotinic acetylcholine receptor (nAChR) modulator with high affinity for the α4β2 nicotinic acetylcholine receptor subtype. ABT-089 displays selective binding to the high-affinity (-)-cytisine binding site with a Ki value of 16 nM and has been widely investigated for its cognition-enhancing properties.
The α4β2 nicotinic acetylcholine receptor is the predominant neuronal nicotinic receptor in the mammalian brain and plays key roles in attention, learning, memory, cognition, and neurotransmitter release. Selective activation of α4β2 nAChRs enhances cholinergic neurotransmission while minimizing activation of other nicotinic receptor subtypes. ABT-089 has been extensively studied in preclinical and clinical settings as a potential therapeutic agent for attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, and cognitive impairment. It serves as a valuable pharmacological tool for investigating cholinergic signaling, nicotinic receptor pharmacology, and cognitive neuroscience.
Key Features
- Potent and selective α4β2 nicotinic acetylcholine receptor modulator
- Ki: 16 nM for the high-affinity α4β2 binding site
- Orally bioavailable compound
- Enhances cognitive function through selective cholinergic modulation
- Useful tool for neuroscience and cognitive research
Applications
- α4β2 nicotinic receptor pharmacology
- Cognition and memory research
- Attention and learning studies
- ADHD and Alzheimer's disease investigations
- Cholinergic neurotransmission research
More Information
| Parent CAS No. | 161417-03-4 |
|---|---|
| Chemical Name | 2-Methyl-3-(((S)-2-pyrrolidinyl)methoxy)pyridine dihydrochloride |
| SMILES | C1=CC=NC(C)=C1OC[C@H]1NCCC1.Cl.Cl |&1:9,r| |
| MFCD | MFCD00929191 |
| InChi | InChI=1S/C11H16N2O.2ClH/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10;;/h3,5-6,10,13H,2,4,7-8H2,1H3;2*1H/t10-;;/m0../s1 |
| InChiKey | UGVSESCRKJTJAK-XRIOVQLTSA-N |
| Short Description | nAChR modulator |
References
- NH Lin et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90.
- JP Sullivan et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46.
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