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Piclamilast
- RP73401
- Soluble in DMSO
- MF: C18H18Cl2N2O3
- MW: 381.25
Description
Piclamilast is a potent and selective PDE4 inhibitor with an IC50 value of 1 nM.
More Information
| Parent CAS No. | 144035-83-6 |
|---|---|
| Chemical Name | 3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide |
| SMILES | C1(OC)C=CC(C(=O)NC2C(Cl)=CN=CC=2Cl)=CC=1OC1CCCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) |
| InChiKey | RRRUXBQSQLKHEL-UHFFFAOYSA-N |
| CID | 154575 |
| Short Description | PDE4 inhibitor |
References
- MJ Ashton et al. Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37(11):1696-703.
- JE Souness et al. Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram. Br J Pharmacol. 1995 May;115(1):39-46.
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