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DTHIB
Axon 3412
CAS:
897326-30-6
Purity:
99%
- Soluble in DMSO
- MF: C13H9ClFN3O3
- MW: 309.68
Description
DTHIB is a direct HSF1 inhibitor with a Kd value of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. Moreover, DTHIB robustly inhibited the HSF1 cancer gene signature and prostate cancer cell proliferation.
More Information
| Parent CAS No. | 897326-30-6 |
|---|---|
| Chemical Name | 1-(4-Chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea |
| SMILES | C1C=C(NC(=O)NC2C=CC(Cl)=C([N+]([O-])=O)C=2)C=CC=1F |
| MFCD | N.A. |
| InChi | InChI=1S/C13H9ClFN3O3/c14-11-6-5-10(7-12(11)18(20)21)17-13(19)16-9-3-1-8(15)2-4-9/h1-7H,(H2,16,17,19) |
| InChiKey | DWVIOMKFHSRQQM-UHFFFAOYSA-N |
| CID | 108866909 |
| Short Description | HSF1 inhibitor |
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