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CCT251236
Axon 2699
CAS:
1693731-40-6
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C32H32N4O5
- MW: 552.62
Description
Highly potent, orally bioavailable inhibitor of the HSF1 stress pathway. CCT251236 displayed the desired balance of in vitro properties, while maintaining excellent cellular activity for inhibition of HSF1-mediated HSP72 induction (IC50 value of 19 nM). Moreover, CCT251236 displayed efficacy in a human ovarian carcinoma xenograft model. Promising chemical probe to investigate the role of HSF1 pathway inhibition and pirin binding in vitro and in vivo.
More Information
| Parent CAS No. | 1693731-40-6 |
|---|---|
| Chemical Name | N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide |
| SMILES | C12OCCOC1=CC(C(=O)NC1C=C(NC(C3C=CC4N=C(OCCN5CCCC5)C=CC=4C=3)=O)C(C)=CC=1)=CC=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C32H32N4O5/c1-21-4-8-25(33-31(37)24-6-10-28-29(19-24)40-17-16-39-28)20-27(21)35-32(38)23-5-9-26-22(18-23)7-11-30(34-26)41-15-14-36-12-2-3-13-36/h4-11,18-20H,2-3,12-17H2,1H3,(H,33,37)(H,35,38) |
| InChiKey | KLHOCHQJHXNKAS-UHFFFAOYSA-N |
| CID | 117996749 |
| Short Description | HSF1 inhibitor |
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