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Axon 1848
CAS [821794-92-7]
MF C18H19FN4O2MW 342.37
Potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; FMK binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. FMK induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.* FMK (IC50 value 15 nM for RSK2 in vitro) is more potent than another CTKD RSK inhibitor SL-0101 (IC50 value 85 nM for RSK2); while BI-D1870 (Axon 1528) binds at NTKD binding site as a reversible RSK inhibitor.
1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone
[821794-92-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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