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Axon 1528
CAS [501437-28-1]
MF C19H23F2N5O2MW 391.42
Potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro (IC50 values 31 nM, 24 nM, 18 nM, and 15 nM, respectively).* BI-D1870 binds at NTKD binding site as a reversible RSK inhibitor, while FMK (Axon 1848) binds at CTKD site as an irreversible RSK inhibitor.
KEYWORDS: BI-D1870 | supplier | RSK inhibitor | BID1870 | BID-1870 | CAS [501437-28-1] | p90-RSK | p90 ribosomal S6 kinase | RSK1 | RSK2 | RSK3 | RSK4 | NTKD binding site | reversible
List of publications using BI-D1870 (Axon 1528) purchased from Axon Medchem
2-(3,5-Difluoro-4-hydroxy-phenylamino)-5,7-dimethyl-8-(3-methyl-butyl)-7,8-dihydro-5H-pteridin-6-one
[501437-28-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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