Anaplastic large-cell lymphomas (ALCLs) are a subtype of the high-grade non-Hodgkin's family of lymphomas with distinct morphology, immunophenotype, and prognosis. ALCLs are postulated to arise from T-cells and, in rare cases, can also exhibit a B cell phenotype. ALCL presents as a systemic disease afflicting skin, bone, soft tissues, and other organs, with or without the involvement of lymph nodes. ALCL can be subdivided into at least two subtypes, characterized by the presence or absence of chromosomal rearrangements between the anaplastic lymphoma kinase (ALK) gene locus and various fusion partners such as nucleophosmin (NPM). NPM-ALK has constitutive tyrosine kinase activity and has been shown to transform various hematopoietic cell types in vitro and support tumor formation in vivo[1].
A small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene, and seems to be the cause of non-small-cell lung cancer (NSCLC) cells. The EML4–ALK fusion transcript is detected in approx. 7% of NSCLC patients[2].

Oncogene Fusion Proteins listed: ALKBCR-ABL

[1] A.V. Galkin et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc. Natl. Acad. Sci. USA 2007, 104 (1), 270-275.
[2] M. Soda et al. Identification of the transformingEML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007, 448, 561-566.

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Axon ID Name Description From price
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
1660 Crizotinib c-MET Inhibitor; NPM-ALK inhibitor €70.00
2294 KRCA 0008 Potent and selective dual ALK/ACK1 inhibitor with good drug-like properties €95.00
1416 NVP-TAE684 NPM-ALK inhibitor €50.00
2600 PF 06463922 Potent, orally available and brain-penetrant ALK/ROS1 selective inhibitor €105.00

6 Item(s)

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