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Axon 4214
CAS [2869954-34-5]
MF C31H31ClF3N9O5MW 702.08
HRO761 is a potent, selective, orally active and allosteric WRN inhibitor (IC50 value of 0.1 μM) that binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation. Pharmacological inhibition by HRO761 recapitulated the phenotype observed by WRN genetic suppression, leading to DNA damage and inhibition of tumour cell growth selectively in MSI cells in a p53-independent manner.
KEYWORDS: HRO761 | Supplier | WRN inhibitor | HRO-761 | HRO 761 | CAS [2869954-34-5] | DNA-RNA | Inhibitor | Enzymes | Hydrolases | MSI cancer | Microsatellite instability | Werner syndrome RecQ helicase
N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide
[2869954-34-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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