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Axon 4102
CAS [2351906-74-4]
MF C18H21N3O4MW 343.38
GA-017 is the first potent LATS1/2 inhibitor that exhibits sufficient growth-promoting effect on a variety of cell types under 3D conditions. GA-017 inhibited the activity of large tumor suppressor kinase 1 and 2 (LATS1/2), components of the Hippo pathway that mediate phosphorylation of YAP/TAZ, with IC50 values of 4.10 nM and 3.92 nM for LATS1 and LATS2, respectively.
KEYWORDS: GA-017 | Supplier | LATS1/2 inhibitor | GA017 | GA 017 | CAS [2351906-74-4] | Non Selective (Serine peptide bonds) | Inhibitor | Enzymes | Transcription Factors
(E)-2-(1-(2,4-dihydroxy-3-methylphenyl)propylidene)-N-(3-hydroxybenzyl)hydrazinecarboxamide
[2351906-74-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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