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NIBR-LTSi dihydrochloride
- Optical Purity: 100% e.e.
- Soluble in water, DMSO and EtOH
- MF: C18H22Cl2N4O
- MW: 381.3
Description
NIBR-LTSi dihydrochloride is a highly selective and orally available LATS kinase inhibitor with an IC50 value of 1.4 nM. NIBR-LTSi activates YAP signaling, exhibits good oral bioavailability, and promotes expansion of organoids derived from multiple mouse and human tissues.
The Hippo-YAP signaling pathway regulates tissue growth, regeneration, stem cell maintenance, and organ size control. In tissue stem cells, NIBR-LTSi promotes proliferation, maintains stemness, and blocks differentiation both in vitro and in vivo, making it a valuable tool for regenerative medicine and organoid research.
Key Features
- Highly selective LATS kinase inhibitor
- IC50: 1.4 nM
- Orally available with good bioavailability
- Activates YAP signaling
- Promotes organoid expansion and stem cell proliferation
Applications
- Hippo-YAP pathway research
- Stem cell biology studies
- Organoid culture and expansion
- Tissue regeneration and repair research
- Liver regeneration and hyperplasia models
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | (R)-N-(4-(Piperidin-3-yloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-amine dihydrochloride |
| SMILES | N1C2NC=CC=2C(NC2C=CC(O[C@@H]3CCCNC3)=CC=2)=CC=1.Cl.Cl |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N4O/c1-2-15(12-19-9-1)23-14-5-3-13(4-6-14)22-17-8-11-21-18-16(17)7-10-20-18/h3-8,10-11,15,19H,1-2,9,12H2,(H2,20,21,22)/t15-/m1/s1 |
| InChiKey | IYFCFYWXRIVCTH-OAHLLOKOSA-N |
| CID | 171115368 |
| Short Description | LATS inhibitor |
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