CASIN is a selective Cdc42 activity inhibitor. Treatment with CASIN (5µM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells. CASIN treatment did not alter cell cycle status or apoptosis in aged LT-HSCs. In response to treatment with CASIN, LT-HSCs from aged mice showed a dose-dependent increase in the percentage of polarized cells, becoming progressively indistinguishable from young cells.

KEYWORDS: CASIN | Supplier | Cdc42 inhibitor | Pirl1-related compound 2 | CAS [425399-05-9] | [1219188-29-0] | Cytoskeleton | CDC42 | Inhibitor | Enzymes | Pirl1 | RhoGTPase Cdc42 | Stem cell aging