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Axon 3917

CAS [2095615-97-5]

MF C21H24N6O4
MW 424.45

  • Purity: 98%
  • Soluble in DMSO



GLPG2534 is a potent, selective and orally active IRAK4 inhibitor with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4. In vitro, IRAK4 inhibition resulted in substantial inhibition of TLR and IL-1 responses in dendritic cells, keratinocytes, granulocytes, and T cells but only weakly affected dermal fibroblast responses. Furthermore, disease activity in murine models of skin inflammation (IL-23–, IL-33–, imiquimod-, and MC903-induced) was markedly dampened by IRAK4 inhibition. Last, inhibiting IRAK4 reversed pathogenic molecular signatures in human lesional psoriasis and atopic dermatitis biopsies.

KEYWORDS: GLPG2534 | IRAK4 inhibitor | GLPG 2534 | GLPG-2534 | CAS [2095615-97-5] | Interleukin | IRAK | Inhibitor | Enzymes | Innate immunity | Inflammatory skin disease | Psoriasis | Atopic dermatitis

Potent, selective and orally active IRAK4 inhibitor

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €150.00 In Stock
25 mg €600.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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