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ZINC69391
Axon 3790
CAS:
303094-67-9
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C14H14F3N5
- MW: 309.29
Description
ZINC69391 is a specific Rac1 inhibitor. ZINC69391 was able to block Rac1 interaction with its GEF Tiam1, prevented EGF-induced Rac1 activation and inhibited cell proliferation, cell migration and cell cycle progression in highly aggressive breast cancer cell lines. Moreover, ZINC69391 inhibited lung metastasis in vivo.
More Information
| Parent CAS No. | 303094-67-9 |
|---|---|
| Chemical Name | 1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-(trifluoromethyl)phenyl)guanidine |
| SMILES | C1(C)N=C(NC(NC2C(C(F)(F)F)=CC=CC=2)=N)N=C(C)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H14F3N5/c1-8-7-9(2)20-13(19-8)22-12(18)21-11-6-4-3-5-10(11)14(15,16)17/h3-7H,1-2H3,(H3,18,19,20,21,22) |
| InChiKey | BEZGMANANMSUSQ-UHFFFAOYSA-N |
| CID | 5728890 |
| Short Description | Rac1-GEF inhibitor |
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