cGAMP - 2', 3'-cyclic GMP-AMP Sodium salt

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Axon 3688

CAS [2734858-36-5]

MF C20H22N10Na2O13P2
MW 718.37

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in Water
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cGAMP

Description

2′,3′-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is the endogenous agonist for the STING (STimulator of INterferon Genes), a receptor crucial to activate the innate immune system. It is a noncanonical cyclic dinucleotide (CDN) produced as a second messenger in mammalian cells by the cytosolic cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. The binding potency of noncanonical 2′,3′-cGAMP for human STING is much better than that of the canonical 3′,3′-cyclic dinucleotides (CDNs) produced in bacterial, with a Kd of 4.6 nM compared to >1 μM for bacterial 3′,3′-CDNs.

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KEYWORDS: cGAMP | STING agonist | 2',3'-cyclic GMP-AMP Sodium salt | CT-CGMAP | CAS [2734858-36-5] | [1441190-66-4] | DNA-CDN | STING | Agonist | Proteins

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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