2′,3′-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is the endogenous agonist for the STING (STimulator of INterferon Genes), a receptor crucial to activate the innate immune system. It is a noncanonical cyclic dinucleotide (CDN) produced as a second messenger in mammalian cells by the cytosolic cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. The binding potency of noncanonical 2′,3′-cGAMP for human STING is much better than that of the canonical 3′,3′-cyclic dinucleotides (CDNs) produced in bacterial, with a Kd of 4.6 nM compared to >1 μM for bacterial 3′,3′-CDNs.

KEYWORDS: cGAMP | STING agonist | 2',3'-cyclic GMP-AMP Sodium salt | CT-CGMAP | CAS [2734858-36-5] | [1441190-66-4] | DNA-CDN | STING | Agonist | Proteins