STING

The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. It is evident that activating STING results in the type I interferon response to protect against infection and tumour formation, while dysregulated gain-of-function STING mutations lead to detrimental consequences of autoimmunity[1].


[1] Li et al. Regulating STING in health and disease. J Inflamm (Lond). 2017 Jun 7;14:11.

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2923 STING inhibitor C-176 Highly potent and selective STING antagonist €95.00

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