E-7766
- Parent CAS: 2242635-02-3
- Optical Purity: 99% e.e.
- Soluble in water
- MF: C24H26F2N10O8P2S2.2NH3
- MW: 780.66
Description
E-7766 is a structurally novel class of macrocyclic molecule, metabolically stable, specific, and potent (Kd in lower nM, on par with that of the natural ligand 2′,3′-cGAMP (Axon 3688) agonist for both human and mouse STING (Stimulator of Interferon Genes). Exhibits broad pan‐genotypic activity in all major human STING variants. Demonstrates potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model.
More Information
| Parent CAS No. | 2242635-02-3 |
|---|---|
| Chemical Name | N.A. |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12N=CN=C3N([C@H]4[C@H](F)[C@@H]5O[P@@](=O)(S)OC[C@@H]6[C@@H](O[P@](OC[C@H]5O4)(=O)S)[C@@H](F)[C@@H](O6)N4C5=NC=NC(=C5N=C4)NCC=CCN1)C=NC=23.N.N |t:46,&1:6,7,9,11,16,17,19,22,26,28,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H26F2N10O8P2S2/c25-13-17-11-5-39-46(38,48)44-18-12(6-40-45(37,47)43-17)42-24(14(18)26)36-10-34-16-20(30-8-32-22(16)36)28-4-2-1-3-27-19-15-21(31-7-29-19)35(9-33-15)23(13)41-11/h1-2,7-14,17-18,23-24H,3-6H2,(H,37,47)(H,38,48)(H,27,29,31)(H,28,30,32)/b2-1-/t11-,12-,13-,14-,17-,18-,23-,24-,45?,46?/m1/s1 |
| InChiKey | YQSAUMRQALUWNS-LFBLFPLGSA-N |
| CID | 163342335 |
| Short Description | STING agonist |
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