Rilpivirine - R278474 | TMC278

Based on 900 reference(s) in Google Scholar 8 10 900

Axon 3685

CAS [500287-72-9]

MF C22H18N6
MW 366.42

Purity: 98%
Soluble in DMSO

Rilpivirine

Description

Rilpivirine is a orally bioavailable non-nucleoside reverse transcriptase inhibitor (NNRTI) which is highly active against wild-type and mutant HIV.

KEYWORDS: Rilpivirine | Supplier | NNRT inhibitor | R278474 | TMC278 | R 278474 | R-278474 | TMC 278 | TMC-278 | CAS [500287-72-9] | [700361-47-3] | DNA-RNA | RT | Inhibitor | Enzymes | Anti-HIV drug | AIDS

PA Janssen et al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). J Med Chem. 2005 Mar 24;48(6):1901-9.

Immunology RT EC 2.7.7.49

Highly active and orally bioavailable NNRT inhibitor (HIV-1)

Chemical name

(E)-4-(4-(4-(2-Cyanovinyl)-2,6-dimethylphenylamino)pyrimidin-2-ylamino)benzonitrile

Parent CAS No.

[500287-72-9]

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Rilpivirine - R278474 | TMC278

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Rilpivirine - R278474 | TMC278

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