RP-6306 - Lunresertib

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3668

CAS [2719793-90-3]

MF C18H20N4O2
MW 324.38

  • Purity: 99%
  • Optical purity: 100% e.e.
  • Soluble in 0.1N HCl(aq), DMSO and EtOH



RP-6306 is a first-in-class, potent, selective, and orally bioavailable PKMYT1 (or MYT1) inhibitor with IC50 values of 0.014 μM and 0.002 μM in cell and nanoBRET assays, respectively. RP-6306 is the active (aS)-atropisomer of the racemate. Its opposite atropisomer, (aR)-RP-6306 (Axon 3759), is also available.

In a recent study, Wee1 inhibitor MK-1775 (Axon 1494) and MYT1 inhibitor RP-6306 (Axon 3668) combination treatment showed synergistic cell killing in a panel of cancer cell lines. Wee1 and MYT1 combined inhibition might be a potential cancer therapeutic strategy.

KEYWORDS: RP-6306 | Supplier | PKMYT1 inhibitor | Lunresertib | RP6306 | RP 6306 | CAS [2719793-90-3] | Cyclin dependent (CDK) | Wee1 | Inhibitor | Enzymes | CDK | Protein kinase | Membrane-associated tyrosine/threonine 1 | Ovarian cancer

Size Unit Price Stock
2 mg €140.00 In Stock
5 mg €280.00 In Stock
25 mg €900.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €480.00 In Stock
2 x 25 mg €1,500.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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