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(aR)-RP-6306
Axon 3759
CAS:
2719793-91-4
- Optical Purity: 98.3% e.e.
- Soluble in DMSO and EtOH
- MF: C18H20N4O2
- MW: 324.38
Description
(aR)-RP-6306 is the opposite atropisomer or (R)-enantiomer of RP-6306 (Axon 3668), which is a PKMYT1 inhibitor.
More Information
| Parent CAS No. | 2719793-91-4 |
|---|---|
| Chemical Name | (R)-2-Amino-1-(3-hydroxy-2,6-dimethyl-phenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide |
| SMILES | C12C(C(=O)N)=C(N)N(C3C(C)=CC=C(O)C=3C)C1=NC(C)=C(C)C=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N4O2/c1-8-5-6-13(23)10(3)15(8)22-16(19)14(17(20)24)12-7-9(2)11(4)21-18(12)22/h5-7,23H,19H2,1-4H3,(H2,20,24) |
| InChiKey | ARBRHWRTXPWZGN-UHFFFAOYSA-N |
| CID | 156869388 |
| Short Description | PKMYT1 inhibitor |
References
- D Gallo et al. CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Nature. 2022 Apr;604(7907):749-756.
- J Szychowski et al. Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 2022 Aug 11;65(15):10251-10284.
- J Szychowski et al. Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use. WO2021195781A1.
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