Homoharringtonine - Omacetaxine mepesuccinate | Ceflatonin | Myelostat

Based on 719 reference(s) in Google Scholar 8 10 719

Axon 3667

CAS [26833-87-4]

MF C29H39NO9
MW 545.62

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO and EtOH

Homoharringtonine

Description

Homoharringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. Additionally, homoharringtonine acts as a potent disrupter of protein-protein interaction interfaces between CDK2 and cyclin A.

K Mazumder et al. A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules. 2022 May 9;27(9):3036.

Zhang et al. Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells. Nat Commun. 2022 May 20;13(1):2835.

M Fresno et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30.

Protein synthesis inhibitor; Binds the 60S ribosomal subunit

Chemical name

1-O-[(2S,3S,6R)-4-Methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

Parent CAS No.

[26833-87-4]

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Homoharringtonine - Omacetaxine mepesuccinate | Ceflatonin | Myelostat

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