Bulk Inquiry
Homoharringtonine
- Omacetaxine mepesuccinate - Ceflatonin - Myelostat
Axon 3667
CAS:
26833-87-4
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C29H39NO9
- MW: 545.62
Description
Homoharringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. Additionally, homoharringtonine acts as a potent disrupter of protein-protein interaction interfaces between CDK2 and cyclin A.
More Information
| Parent CAS No. | 26833-87-4 |
|---|---|
| Chemical Name | 1-O-[(2S,3S,6R)-4-Methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate |
| SMILES | C12OCOC=1C=C1[C@]3([H])[C@H](OC(=O)[C@@](O)(CCCC(O)(C)C)CC(OC)=O)C(OC)=C[C@]43CCCN4CCC1=C2 |&1:7,9,13,31,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1 |
| InChiKey | HYFHYPWGAURHIV-JFIAXGOJSA-N |
| CID | 285033 |
| Short Description | Protein synthesis inhibitor |
References
- K Mazumder et al. A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules. 2022 May 9;27(9):3036.
- Zhang et al. Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells. Nat Commun. 2022 May 20;13(1):2835.
- M Fresno et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30.
Other Categories
Get a Quote for
Loading...