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SGC-SMARCA-BRDVIII
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C19H25N5O3
- MW: 371.43
Description
SGC-SMARCA-BRDVIII is a potent, highly selective and cell-active SMARCA2/4 and PB1(5) bromodomain inhibitor with Kd values of 35, 36 and 13 nM, respectively. SGC-SMARCA-BRDVIII blocked adipogenesis of 3T3-L1 murine fibroblasts by reducing the mRNA levels of key markers of adipocyte differentiation, PPARγ,C/EBPα, and FABP4.
More Information
| Parent CAS No. | 1997319-84-2 |
|---|---|
| Chemical Name | tert-Butyl 4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazine-1-carboxylate |
| SMILES | C1C=C(O)C(C2N=NC(N)=C(N3CCN(C(OC(C)(C)C)=O)CC3)C=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25N5O3/c1-19(2,3)27-18(26)24-10-8-23(9-11-24)15-12-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,12,25H,8-11H2,1-3H3,(H2,20,22) |
| InChiKey | AQTNUGRRZDRZIA-UHFFFAOYSA-N |
| CID | 137045929 |
| Short Description | SMARCA2/4/PB1(5) inhibitor |
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