Carvedilol is a β-adrenoceptor antagonist which also causes peripheral vasodilation primarily via α1-adrenergic blockade (Ki values of 0.81, 0.96 and 2.2 nM for β1-, β2-, and α1-adrenoceptors, respectively). Carvedilol produces its antihypertensive effect partly by reducing total peripheral resistance by blocking α1-adrenoceptors and by preventing β-adrenoceptor-mediated compensatory mechanisms.

KEYWORDS: Carvedilol | Supplier | β/α1 antagonist | BM14190 | BM 14190 | BM-14190 | CAS [72956-09-3] | [374779-42-7] | [374779-43-8] | [374779-45-0] | (Nor-)Adrenaline | Adrenoceptor α1 | Adrenoceptor β1 | Adrenoceptor β2 | Antagonist | Receptors