GNF362

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3434

CAS [1003019-41-7]

MF C22H21F3N6
MW 426.44

  • Purity: 99%
  • Optical purity: 99.1% e.e.
  • Soluble in DMSO and EtOH
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GNF362

Description

GNF362 is a potent, selective and orally bioavailable Itpkb inhibitor with an IC50 value of 9nM. Application of GNF362 to lymphocytes in vitro, blocked Ins(1,3,4,5)P4 production, enhanced antigen receptor-driven Ca2+ responses and lead to apoptosis of activated T cells in an Itpkb-dependent manner.

KEYWORDS: GNF362 | Supplier | ITPKB inhibitor | GNF 362 | GNF-362 | CAS [1003019-41-7] | Inositol-1,4,5-trisphosphate (InsP3) | ITPKB | Inhibitor | Enzymes | Autoimmune disease | Arthritis | T cell | Graft-versus-host disease | Inositol 1,4,5-trisphosphate 3-kinase B

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Size Unit Price Stock
5 mg €150.00 In Stock
25 mg €550.00 In Stock
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2 x 5 mg €240.00 In Stock
2 x 25 mg €880.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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