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GNF362
Axon 3434
CAS:
1003019-41-7
- Optical Purity: 99% e.e.
- Soluble in DMSO and EtOH
- MF: C22H21F3N6
- MW: 426.44
Description
GNF362 is a potent, selective and orally bioavailable Itpkb inhibitor with an IC50 value of 9nM. Application of GNF362 to lymphocytes in vitro, blocked Ins(1,3,4,5)P4 production, enhanced antigen receptor-driven Ca2+ responses and lead to apoptosis of activated T cells in an Itpkb-dependent manner.
More Information
| Parent CAS No. | 1003019-41-7 |
|---|---|
| Chemical Name | (R)-4-(4-((3-Methyl-4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methyl)-1H-pyrazol-3-yl)benzonitrile |
| SMILES | C1(C#N)C=CC(C2C(CN3C[C@@H](C)N(C4C=CC(C(F)(F)F)=CN=4)CC3)=CNN=2)=CC=1 |&1:11,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21F3N6/c1-15-13-30(8-9-31(15)20-7-6-19(12-27-20)22(23,24)25)14-18-11-28-29-21(18)17-4-2-16(10-26)3-5-17/h2-7,11-12,15H,8-9,13-14H2,1H3,(H,28,29)/t15-/m1/s1 |
| InChiKey | VNTCGXMLDSKOKN-OAHLLOKOSA-N |
| CID | 57999583 |
| Short Description | ITPKB inhibitor |
References
- AT Miller et al. Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS One. 2015 Jun 29;10(6):e0131071.
- G Thangavelu et al. Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood. 2020 Jan 2;135(1):28-40.
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