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Axon 3434
CAS [1003019-41-7]
MF C22H21F3N6MW 426.44
GNF362 is a potent, selective and orally bioavailable Itpkb inhibitor with an IC50 value of 9nM. Application of GNF362 to lymphocytes in vitro, blocked Ins(1,3,4,5)P4 production, enhanced antigen receptor-driven Ca2+ responses and lead to apoptosis of activated T cells in an Itpkb-dependent manner.
KEYWORDS: GNF362 | Supplier | ITPKB inhibitor | GNF 362 | GNF-362 | CAS [1003019-41-7] | Inositol-1,4,5-trisphosphate (InsP3) | ITPKB | Inhibitor | Enzymes | Autoimmune disease | Arthritis | T cell | Graft-versus-host disease | Inositol 1,4,5-trisphosphate 3-kinase B
(R)-4-(4-((3-Methyl-4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methyl)-1H-pyrazol-3-yl)benzonitrile
[1003019-41-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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