ARB-272572 - PD-L1 inhibitor compound A

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3433

CAS [2368182-63-0]

MF C32H36N6O4
MW 568.67

  • Purity: 99%
  • Soluble in 0.1N HCl(aq), DMSO and EtOH



ARB-272572 is a potent, cellular active PD-L1 inhibitor with an IC50 value of 400 pM for inhibition of PD-1/PD-L1 cell signaling (HTRF assay). ARB-272572 inhibits the PD-1/PD-L1 axis by inducing cell surface PD-L1 dimerization followed by rapid internalization into the cytosol. In addition, ARB-272572 is the first small-molecule checkpoint inhibitor inducing T cell proliferative and IFNγ responses to HBV peptides.

KEYWORDS: ARB-272572 | Supplier | PD-L1 inhibitor | PD-L1 inhibitor compound A | ARB272572 | ARB 272572 | CAS [2368182-63-0] | [2377524-19-9] | T-Cell activity | PD-1 | Inhibitor | Proteins | Colorectal cancer | Programmed cell death-ligand 1 | CD274 | B7 homolog 1 | Hepatitis B

Size Unit Price Stock
5 mg €150.00 In Stock
25 mg €550.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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