ARB-272572 is a potent, cellular active PD-L1 inhibitor with an IC50 value of 400 pM for inhibition of PD-1/PD-L1 cell signaling (HTRF assay). ARB-272572 inhibits the PD-1/PD-L1 axis by inducing cell surface PD-L1 dimerization followed by rapid internalization into the cytosol. In addition, ARB-272572 is the first small-molecule checkpoint inhibitor inducing T cell proliferative and IFNγ responses to HBV peptides.

KEYWORDS: ARB-272572 | Supplier | PD-L1 inhibitor | PD-L1 inhibitor compound A | ARB272572 | ARB 272572 | CAS [2368182-63-0] | [2377524-19-9] | T-Cell activity | PD-1 | Inhibitor | Proteins | Colorectal cancer | Programmed cell death-ligand 1 | CD274 | B7 homolog 1 | Hepatitis B