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PD-1 Inhibitor 16
- Aurigene Compound 16
Axon 3694
CAS:
2005454-12-4
- Optical Purity: 99% e.e.
- Soluble in water and DMSO
- MF: C14H23N7O6
- MW: 385.38
Description
PD-1 Inhibitor 16 (extracted from Patent (compound 16, ref 1)) is an orally bioavailable small molecule peptidomimetic inhibitor of the immune checkpoint regulatory proteins PD-I/PD-L1 (programmed cell death -1/programmed cell death ligand-1) interaction, with signaling activity in cancer cells, and is currently being evaluated as a potential negative immune checkpoint regulatory and antineoplastic agent.
More Information
| Parent CAS No. | 2005454-12-4 |
|---|---|
| Chemical Name | (2S,3S)-2-(3-((S)-3-amino-3-oxo-1-(3-(piperazin-1-yl)-1,2,4-oxadiazol-5-yl)propyl)ureido)-3-hydroxybutanoic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(ON=C(N2CCNCC2)N=1)[C@H](CC(=O)N)NC(=O)N[C@@H](C(O)C)C(=O)O |&1:11,20,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C14H23N7O6/c1-7(22)10(12(24)25)18-14(26)17-8(6-9(15)23)11-19-13(20-27-11)21-4-2-16-3-5-21/h7-8,10,16,22H,2-6H2,1H3,(H2,15,23)(H,24,25)(H2,17,18,26)/t7?,8-,10-/m0/s1 |
| InChiKey | RKAIKBRLPZSBRN-CFGJQEBVSA-N |
| CID | 122541438 |
| Short Description | PD-1 inhibitor |
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