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ARB-272572
- PD-L1 inhibitor compound A
Axon 3433
CAS:
2368182-63-0
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C32H36N6O4
- MW: 568.67
Description
ARB-272572 is a potent, cellular active PD-L1 inhibitor with an IC50 value of 400 pM for inhibition of PD-1/PD-L1 cell signaling (HTRF assay). ARB-272572 inhibits the PD-1/PD-L1 axis by inducing cell surface PD-L1 dimerization followed by rapid internalization into the cytosol. In addition, ARB-272572 is the first small-molecule checkpoint inhibitor inducing T cell proliferative and IFNγ responses to HBV peptides.
More Information
| Parent CAS No. | 2368182-63-0 |
|---|---|
| Chemical Name | N,N'-(2,2'-Dimethylbiphenyl-3,3'-diyl)bis(5-((2-hydroxyethylamino)methyl)picolinamide) |
| SMILES | C1C=C(C(=O)NC2C=CC=C(C3C(C)=C(NC(=O)C4N=CC(CNCCO)=CC=4)C=CC=3)C=2C)N=CC=1CNCCO |
| MFCD | N.A. |
| InChi | InChI=1S/C32H36N6O4/c1-21-25(5-3-7-27(21)37-31(41)29-11-9-23(19-35-29)17-33-13-15-39)26-6-4-8-28(22(26)2)38-32(42)30-12-10-24(20-36-30)18-34-14-16-40/h3-12,19-20,33-34,39-40H,13-18H2,1-2H3,(H,37,41)(H,38,42) |
| InChiKey | FZEPAZRIEAMJFE-UHFFFAOYSA-N |
| CID | 139537190 |
| Short Description | PD-L1 inhibitor |
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