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BMS202 hydrochloride
- PCC0208025
Axon 4247
- Parent CAS: 1675203-84-5
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C25H29N3O3.HCl
- MW: 455.98
Description
BMS202 hydrochloride is a PD-1/PD-L1 interaction inhibitor with an IC50 value of 18 nM.
More Information
| Parent CAS No. | 1675203-84-5 |
|---|---|
| Chemical Name | N-(2-((2-Methoxy-6-((2-methylbiphenyl-3-yl)methoxy)pyridin-3-yl)methylamino)ethyl)acetamide hydrochloride |
| SMILES | C1(C2C=CC=CC=2)C(C)=C(COC2C=CC(CNCCNC(=O)C)=C(OC)N=2)C=CC=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C25H29N3O3.ClH/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29;/h4-13,26H,14-17H2,1-3H3,(H,27,29);1H |
| InChiKey | XGIQBUNWFCCMAS-UHFFFAOYSA-N |
| CID | 127263272 |
| Short Description | PD-1/PD-L1 inhibitor |
References
- K Guzik et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.
- Z Hu et al. PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice. PLoS One. 2020 Mar 26;15(3):e0228339.
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