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URB937
Axon 3359
CAS:
1357160-72-5
Purity:
99%
- Soluble in DMSO
- MF: C20H22N2O4
- MW: 354.4
Description
URB937 is a potent, orally available, and peripherally restricted FAAH inhibitor with an IC50 value of 26.8 nM. URB937 exerts profound analgesic effects in animal models.
More Information
| Parent CAS No. | 1357160-72-5 |
|---|---|
| Chemical Name | 3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate |
| SMILES | C1(OC(=O)NC2CCCCC2)C=C(C2C=C(C(N)=O)C=CC=2)C(O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25) |
| InChiKey | CMEQHOXCIGFZNJ-UHFFFAOYSA-N |
| CID | 53394762 |
| Short Description | FAAH inhibitor |
References
- V Vozella et al. Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats. J Pharm Pharmacol. 2019 Dec;71(12):1762-1773.
- JR Clapper et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct;13(10):1265-70.
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