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SR-717 lithium
Axon 3336
- Parent CAS: 2375420-34-9
Purity:
99%
- Soluble in water and DMSO
- MF: C15H8F2LiN5O3
- MW: 351.19
Description
SR-717 lithium is a non-nucleotide STING agonist and cGAMP mimetic with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 lithium displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 lithium also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
More Information
| Parent CAS No. | 2375420-34-9 |
|---|---|
| Chemical Name | Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate |
| SMILES | N1N=C(C(=O)NC2C=C(F)C(F)=CC=2C(=O)[O-])C=CC=1N1C=CN=C1.[Li+] |
| MFCD | N.A. |
| InChi | InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1 |
| InChiKey | ODSAJRWPLSVEHJ-UHFFFAOYSA-M |
| CID | 139434658 |
| Short Description | STING agonist |
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