SR-717 lithium

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3336

CAS [2375421-09-1]

MF C15H8F2LiN5O3
MW 351.19

  • Purity: 99%
  • Soluble in DMSO
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SR-717 lithium

Description

SR-717 lithium is a non-nucleotide STING agonist and cGAMP mimetic with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 lithium displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 lithium also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

KEYWORDS: SR-717 lithium | supplier | STING agonist | SR717 lithium | SR 717 lithium | CAS [2375421-09-1] | [2375420-34-9] | DNA-CDN | STING | Agonist | Proteins | Stimulator of interferon genes

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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