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Sofosbuvir
- PSI7977 - GS7977
Axon 3302
CAS:
1190307-88-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H29FN3O9P
- MW: 529.45
Description
Sofosbuvir, a methyluridine nucleotide prodrug, is a potent and selective inhibitor of the HCV NS5B polymerase.
More Information
| Parent CAS No. | 1190307-88-0 |
|---|---|
| Chemical Name | (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate |
| SMILES | [C@@H]1(O)[C@@H](CO[P@@](N[C@@H](C)C(=O)OC(C)C)(OC2C=CC=CC=2)=O)O[C@@H](N2C=CC(=O)NC2=O)[C@@]1(F)C |&1:0,2,5,7,24,33,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1 |
| InChiKey | TTZHDVOVKQGIBA-IQWMDFIBSA-N |
| CID | 45375808 |
| Short Description | NS5B polymerase inhibitor |
References
- MJ Sofia et al. Discovery of a β-D-20 -Deoxy-20 -r-fluoro-20 -β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus. J Med Chem. 2010 Oct 14;53(19):7202-18.
- E Murakami et al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J Biol Chem 2010 Nov 5;285(45):34337-47.
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