Sofosbuvir - PSI7977 | GS7977

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3301

CAS [1190307-88-0]

MF C22H29FN3O9P
MW 529.45

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO

Sofosbuvir

Description

Sofosbuvir, a methyluridine nucleotide prodrug, is a potent and selective inhibitor of the HCV NS5B polymerase.

KEYWORDS: Sofosbuvir | supplier | NS5B polymerase inhibitor | PSI7977 | GS7977 | PSI 7977 | PSI-7977 | GS 7977 | GS-7977 | CAS [1190307-88-0] | DNA-RNA | RNA | Inhibitor | Enzymes | Hepatitis C virus

MJ Sofia et al. Discovery of a β-D-20 -Deoxy-20 -r-fluoro-20 -β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus. J Med Chem. 2010 Oct 14;53(19):7202-18.

E Murakami et al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J Biol Chem 2010 Nov 5;285(45):34337-47.

Potent and selective HCV NS5B polymerase inhibitor

Chemical name

(S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Parent CAS No.

[1190307-88-0]

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Sofosbuvir - PSI7977 | GS7977

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Sofosbuvir - PSI7977 | GS7977

Description

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