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DDO-6600
Axon 3264
CAS:
2640292-37-9
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C26H28N4O2
- MW: 428.53
Description
DDO-6600 is a targeted covalent inhibitor of heat shock protein 90 (Hsp90). DDO-6600 covalently bound to Cys598 on the Hsp90 C terminus and exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.
More Information
| Parent CAS No. | 2640292-37-9 |
|---|---|
| Chemical Name | (E)-1-(3-(3-(3,4-Dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl)acryloyl)piperidine-2-carboxamide |
| SMILES | C1(C(=O)N)N(C(/C=C/C2=CN(C3C=CC=CC=3)N=C2C2C=C(C)C(C)=CC=2)=O)CCCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H28N4O2/c1-18-11-12-20(16-19(18)2)25-21(17-30(28-25)22-8-4-3-5-9-22)13-14-24(31)29-15-7-6-10-23(29)26(27)32/h3-5,8-9,11-14,16-17,23H,6-7,10,15H2,1-2H3,(H2,27,32)/b14-13+ |
| InChiKey | SKDKPKFZKHHGCG-BUHFOSPRSA-N |
| CID | 16281823 |
| Short Description | Hsp90 inhibitor |
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