CXL146 is a selective inhibitor of HL60/MX2 cell proliferation by targeting GRP78 overexpression. CXL146 treatment activated the unfolded protein response (UPR). CXL146-induced UPR activation led to a series of downstream events, including extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation, which contributed to CXL146-induced apoptosis.

KEYWORDS: CXL146 | supplier | GRP78 inhibitor | CXL 146 | CXL-146 | CAS [2244586-41-0] | Unfolded Protein Response (Non Selective) | Hsp70 | Inhibitor | Enzymes | GRP78 | Multidrug resistance | HSPA5 | Binding immunoglobulin protein | BiP | ER stress