Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3261

CAS [2244586-41-0]

MF C24H20N2O5
MW 416.43

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO



CXL146 is a selective inhibitor of HL60/MX2 cell proliferation by targeting GRP78 overexpression. CXL146 treatment activated the unfolded protein response (UPR). CXL146-induced UPR activation led to a series of downstream events, including extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation, which contributed to CXL146-induced apoptosis.

KEYWORDS: CXL146 | supplier | GRP78 inhibitor | CXL 146 | CXL-146 | CAS [2244586-41-0] | Unfolded Protein Response (Non Selective) | Hsp70 | Inhibitor | Enzymes | GRP78 | Multidrug resistance | HSPA5 | Binding immunoglobulin protein | BiP | ER stress

Size Unit Price Stock
5 mg €130.00 In Stock
25 mg €460.00 In Stock
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Size Unit Price Stock
2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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