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ML346
- CID 767276
- Soluble in DMSO
- MF: C14H12N2O4
- MW: 272.26
Description
ML346 (CID 767276) is a cell-active activator of the heat-shock response and Hsp70 expression, with an EC50 of 4.6 µM in HeLa cells. It induces HSF1-dependent expression of molecular chaperones, including Hsp70, Hsp40, and Hsp27, and also engages broader proteostasis programs involving oxidative-stress and unfolded-protein-response pathways.
ML346 restores protein folding and function in cellular models of conformational disease, including rescue of mutant CFTR-dependent ion transport, without significant cytotoxicity at active concentrations. It is useful for studying pharmacological reinforcement of the proteostasis network, HSF1-regulated chaperone expression, and the capacity of stress-response pathways to reduce misfolded-protein burden.
Key Features
- Cell-active activator of Hsp70 expression
- EC50: 4.6 µM in HeLa cells
- Activates HSF1-dependent chaperone transcription
- Induces Hsp70, Hsp40, and Hsp27
- Restores protein folding in conformational-disease models
Applications
- Hsp70 and heat-shock response research
- HSF1-dependent transcription
- Protein folding and cellular proteostasis
- CFTR and conformational-disease models
- Oxidative and endoplasmic-reticulum stress studies
More Information
| Parent CAS No. | 100872-83-1 |
|---|---|
| Chemical Name | 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione |
| SMILES | C1C=C(/C=C/C=C2/C(=O)NC(=O)NC/2=O)C=CC=1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H,1H3,(H2,15,16,17,18,19)/b3-2+ |
| InChiKey | IXYLVJHFJKDHRM-NSCUHMNNSA-N |
| CID | 767276 |
| Short Description | Hsp70 activator |
References
- B Calamini et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Dec 17
- B Calamini et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96.
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