RET agonist Q525 is a highly selective RET agonist which afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. It was active in MG87 RET/GFRa1 cells across a broad range of concentrations and generated large and significant increases in pAkt/pErk. It maintained a high degree of selectivity for RET, because no significant increases in pAkt and pErk were observed in MG87 TrkA cells.

KEYWORDS: RET agonist Q525 | supplier | RET agonist | RET agonist Q 525 | RET agonist Q-525 | CAS [2927469-43-8] | GDNF | RET | agonist | Receptors | Retinitis pigmentosa | Retinal degeneration