RET agonist Q525

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3226

CAS [N.A.]

MF C16H11ClN2O3
MW 314.72

  • Purity: 98%
  • Soluble in DMSO

RET agonist Q525

Description

RET agonist Q525 is a highly selective RET agonist which afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. It was active in MG87 RET/GFRa1 cells across a broad range of concentrations and generated large and significant increases in pAkt/pErk. It maintained a high degree of selectivity for RET, because no significant increases in pAkt and pErk were observed in MG87 TrkA cells.

KEYWORDS: RET agonist Q525 | supplier | RET agonist | RET agonist Q 525 | RET agonist Q-525 | CAS [N.A.] | GDNF | RET | agonist | Receptors | Retinitis pigmentosa | Retinal degeneration

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

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