Order

Size
Price
Stock
Qty

RET Inhibitor 2667

Axon 2667
CAS:  1980023-80-0
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C26H25FN10O
  • MW:  512.54

Description

RET Inhibitor 2667 (CAS 1980023-80-0) is a potent RET inhibitor with an IC50 value below10 nM, displaying activity against wild-type RET and its mutants.

RET pharmacology is relevant to cancer and oncology; RET Inhibitor 2667 supports mechanistic studies of RET, RTK, GDNF in biochemical, cellular and disease-model assays.

Key Features

  • RET inhibitor for interrogation of RET biology
  • IC50 value
  • Modulates RET-dependent downstream signaling and functional biological activity
  • Supports focused RET pathway studies in biochemical and cellular systems

Applications

  • Evaluating RET pharmacology and therapeutic target validation
  • Probing RET-dependent pathways and intracellular cascades
  • Investigating oncogenic mechanisms in breast and general cancers
  • Profiling receptor signaling, ligand bindings, and biological actions

More Information

Parent CAS No. 1980023-80-0
Chemical Name (S)-N-(1-(6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)-3-methyl-5-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)picolinamide
SMILES C1(NC2=NNC(C)=C2)N=C(C2C=NC(C(=O)N[C@@H](C)C3C=CC(N4N=CC(F)=C4)=NC=3)=C(C)C=2)N=C(C)C=1 |&1:17,r|
MFCD N.A.
InChi InChI=1S/C26H25FN10O/c1-14-7-19(25-31-15(2)8-21(34-25)33-22-9-16(3)35-36-22)11-29-24(14)26(38)32-17(4)18-5-6-23(28-10-18)37-13-20(27)12-30-37/h5-13,17H,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t17-/m0/s1
InChiKey DAFQECVJVSAYPF-KRWDZBQOSA-N
CID 122487497
Short Description RET inhibitor

Related Products

AXON ID NAME FROM PRICE
1411 Vandetanib

From $55.00

1819 Cabozantinib S-malate

From $66.00

3195 Selpercatinib

From $121.00

3226 RET agonist Q525

From $132.00

3854 BLU-667

From $143.00

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

Loading...