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RET agonist Q525
Axon 3226
CAS:
2927469-43-8
Purity:
98%
- Soluble in DMSO
- MF: C16H11ClN2O3
- MW: 314.72
Description
RET agonist Q525 is a highly selective RET agonist which afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. It was active in MG87 RET/GFRa1 cells across a broad range of concentrations and generated large and significant increases in pAkt/pErk. It maintained a high degree of selectivity for RET, because no significant increases in pAkt and pErk were observed in MG87 TrkA cells.
More Information
| Parent CAS No. | 2927469-43-8 |
|---|---|
| Chemical Name | 7-Chloro-6-(4-(hydroxymethyl)phenylamino)quinoline-5,8-dione |
| SMILES | C1C=C2C(=O)C(NC3C=CC(CO)=CC=3)=C(Cl)C(=O)C2=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H11ClN2O3/c17-12-14(19-10-5-3-9(8-20)4-6-10)15(21)11-2-1-7-18-13(11)16(12)22/h1-7,19-20H,8H2 |
| InChiKey | FKTXGYUFKHBCIY-UHFFFAOYSA-N |
| CID | 155903166 |
| Short Description | RET agonist |
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