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BLU-667

 - Pralsetinib  - RG 6396
Axon 3854
CAS:  2097132-94-8
  • Optical Purity:  Optically pure
  • Soluble in DMSO and EtOH
  • MF:  C27H32FN9O2
  • MW:  533.6

Description

BLU-667 is a highly potent and selective RET inhibitor with an IC50 value of 0.4 nM. In vivo, BLU-667 potently inhibited growth of NSCLC and thyroid cancer xenografts driven by various RET mutations and fusions without inhibiting VEGFR2.

More Information

Parent CAS No. 2097132-94-8
Chemical Name (1s,4R)-N-((S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)-1-methoxy-4-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)cyclohexanecarboxamide
SMILES C1(C)C=C(NC2C=C(C)NN=2)N=C([C@@H]2CC[C@@](OC)(C(=O)N[C@@H](C)C3C=NC(N4C=C(F)C=N4)=CC=3)CC2)N=1 |&1:13,16,22,r|
MFCD N.A.
InChi InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19?,27?/m0/s1
InChiKey GBLBJPZSROAGMF-SIYOEGHHSA-N
CID 129073603
Short Description RET inhibitor

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