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RIG012
Axon 3215
CAS:
2642218-43-5
Purity:
99%
- Soluble in DMSO
- MF: C23H21NO3
- MW: 359.42
Description
RIG012 is a potent RIG-I antagonist with an IC50 value of 0.71 μM. It inhibits RIG-I signaling and downstream interferon response in living cells.
RIG-I (DDX58) is a cytosolic RNA sensor involved in antiviral innate immunity and type I interferon production, making it a relevant target for studies in inflammation, autoimmune disease, and antiviral responses.
Key Features
- Potent RIG-I antagonist
- IC50: 0.71 μM
- Inhibits RIG-I signaling in living cells
- Reduces interferon response
Applications
- RIG-I and RLR pathway research
- Innate immune signaling studies
- Interferon response modulation
- RNA sensing and antiviral pathways
- Inflammation and autoimmune disease models
More Information
| Parent CAS No. | 2642218-43-5 |
|---|---|
| Chemical Name | 4-(Benzyloxy)-3,3-diethyl-2H-benzo[g]indole-2,5(3H)-dione |
| SMILES | C1C=C2C3=NC(=O)C(CC)(CC)C3=C(OCC3C=CC=CC=3)C(=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H21NO3/c1-3-23(4-2)18-19(24-22(23)26)16-12-8-9-13-17(16)20(25)21(18)27-14-15-10-6-5-7-11-15/h5-13H,3-4,14H2,1-2H3 |
| InChiKey | OEWZCENSPLZNPQ-UHFFFAOYSA-N |
| CID | 154717119 |
| Short Description | RIG-I antagonist |
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