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Axon 3202
CAS [2393840-15-6]
MF C24H31N5O2MW 421.54
LEI-401 is a first-in-class, potent, selective and CNS-active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki value of 0.027 μM). LEI-401 blocks NAE biosynthesis in the brain of freely moving mice, thereby revealing a possible endogenous tone of this lipid family in emotional behavior. Moreover, LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.
KEYWORDS: LEI-401 | supplier | NAPE-PLD inhibitor | LEI 401 | LEI401 | CAS [2393840-15-6] | Phosphatidylcholine | PLD | Inhibitor | Enzymes | N-acylethanolamines | NAE
N-(Cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide
[2393840-15-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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