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LEI-401
- Optical Purity: 99.9% e.e.
- Soluble in DMSO
- MF: C24H31N5O2
- MW: 421.54
Description
LEI-401 is a first-in-class, potent, selective and CNS-active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki value of 0.027 μM). LEI-401 blocks NAE biosynthesis in the brain of freely moving mice, thereby revealing a possible endogenous tone of this lipid family in emotional behavior. Moreover, LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.
More Information
| Parent CAS No. | 2393840-15-6 |
|---|---|
| Chemical Name | N-(Cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide |
| SMILES | C1C=CC([C@@H]2CCCN(C3N=C(N4C[C@@H](O)CC4)C=C(C(=O)NCC4CC4)N=3)C2)=CC=1 |&1:4,14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H31N5O2/c30-20-10-12-28(16-20)22-13-21(23(31)25-14-17-8-9-17)26-24(27-22)29-11-4-7-19(15-29)18-5-2-1-3-6-18/h1-3,5-6,13,17,19-20,30H,4,7-12,14-16H2,(H,25,31)/t19-,20+/m1/s1 |
| InChiKey | GFHJYPQZBBHOCC-UXHICEINSA-N |
| CID | 145998143 |
| Short Description | NAPE-PLD inhibitor |
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