Bulk Inquiry
Topiroxostat
Axon 3178
CAS:
577778-58-6
Purity:
99%
- Soluble in DMSO
- MF: C13H8N6
- MW: 248.24
Description
Topiroxostat is a potent xanthine oxidoreductase (XOR) inhibitor with xanthine as a substrate. In the absence of xanthine, however, FYX-051 itself is very slowly hydroxylated by the enzyme.
More Information
| Parent CAS No. | 577778-58-6 |
|---|---|
| Chemical Name | 4-(5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl)picolinonitrile |
| SMILES | N1C=CC(C2=NC(C3C=C(C#N)N=CC=3)=NN2)=CC=1 |
| MFCD | MFCD17167057 |
| InChi | InChI=1S/C13H8N6/c14-8-11-7-10(3-6-16-11)13-17-12(18-19-13)9-1-4-15-5-2-9/h1-7H,(H,17,18,19) |
| InChiKey | UBVZQGOVTLIHLH-UHFFFAOYSA-N |
| CID | 5288320 |
| Short Description | XOR inhibitor |
References
- K Okamoto et al. The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition. Proc Natl Acad Sci U S A 2004 May 25;101(21):7931-6.
- T Nakamura et al. Effects of topiroxostat and febuxostat on urinary albumin excretion and plasma xanthine oxidoreductase activity in db/db mice. Eur J Pharmacol. 2016 Jun 5;780:224-31.
- T Sato et al. Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected]. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1174 | Niraxostat |
From $143.00 |
| 1175 | TEI 6720 |
From $99.00 |
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.