Leflunomide

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3164

CAS [75706-12-6]

MF C12H9F3N2O2
MW 270.21

Purity: 99%
Soluble in DMSO

Leflunomide

Description

Leflunomide is a selective inhibitor of de novo pyrimidine synthesis. The active metabolite of Leﬂunomide, A77 1726, at low, therapeutically applicable doses, reversibly inhibits dihydroorotate dehydrogenase (DHODH), the rate limiting step in the de novo synthesis of pyrimidines. Leflunomide is a disease modifying antirheumatic drug (DMARD).

RR Bartlett et al. Immunopharmacological Profile of a Novel Isoxazol Derivative, HWA 486, With Potential Antirheumatic activity--I. Disease Modifying Action on Adjuvant Arthritis of the Rat. Int J Immunopharmacol. 1985;7(1):7-18.

F Breedveld et al. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000 Nov; 59(11): 841–849.

Selective inhibitor of de novo pyrimidine synthesis; DMARD

Chemical name

5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

Parent CAS No.

[75706-12-6]

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