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Leflunomide
Axon 3164
CAS:
75706-12-6
Purity:
99%
- Soluble in DMSO
- MF: C12H9F3N2O2
- MW: 270.21
Description
Leflunomide is a selective inhibitor of de novo pyrimidine synthesis. The active metabolite of Leflunomide, A77 1726, at low, therapeutically applicable doses, reversibly inhibits dihydroorotate dehydrogenase (DHODH), the rate limiting step in the de novo synthesis of pyrimidines. Leflunomide is a disease modifying antirheumatic drug (DMARD).
More Information
| Parent CAS No. | 75706-12-6 |
|---|---|
| Chemical Name | 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide |
| SMILES | N1=CC(C(=O)NC2C=CC(C(F)(F)F)=CC=2)=C(C)O1 |
| MFCD | MFCD00867593 |
| InChi | InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
| InChiKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| CID | 3899 |
| Short Description | DHODH inhibitor |
References
- RR Bartlett et al. Immunopharmacological Profile of a Novel Isoxazol Derivative, HWA 486, With Potential Antirheumatic activity--I. Disease Modifying Action on Adjuvant Arthritis of the Rat. Int J Immunopharmacol. 1985;7(1):7-18.
- F Breedveld et al. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000 Nov; 59(11): 841–849.
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