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CU-115
Axon 3155
CAS:
2471982-20-2
Purity:
98%
- Soluble in DMSO
- MF: C21H11F7INO2
- MW: 569.21
Description
CU-115 is a selective TLR8 inhibitor (IC50 value of 1.04 μM). Biological evaluation of CU-115 using human monocyte THP-1, RAW264.7, and Hek 293-Blue TLR cells confirmed that CU-115 is active for inhibiting ssRNA-sensing pathways at low concentrations and does not inhibit other non-endosomal TLR and cytosolic NA-sensing pathways (<5 μ M).
More Information
| Parent CAS No. | 2471982-20-2 |
|---|---|
| Chemical Name | N-(4-(3,5-Bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide |
| SMILES | C1(C(F)(F)F)C=C(OC2C=CC(NC(=O)C3C(F)=CC=CC=3I)=CC=2)C=C(C(F)(F)F)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31) |
| InChiKey | QYSLCRYVUJORPX-UHFFFAOYSA-N |
| CID | 154734323 |
| Short Description | TLR8 inhibitor |
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