DC260126 is a GPR40 antagonist with an IC50 value of 6.58 μM. DC260126 improves insulin tolerance but not glucose tolerance in obese Zucker rats. Although DC260126 could not provide benefit for improving hyperglycemia, it could protect against pancreatic b-cells dysfunction through reducing overload of b-cells, and it increases insulin sensitivity possibly via alleviation of hyperinsulinemia in db/db mice.

KEYWORDS: DC260126 | GPR40 antagonist | DC 260126 | DC-260126 | CAS [346692-04-4] | FFA | GPR40 | Antagonist | Receptors | Insulin | Glucose | Zucker | Hyperglycemia