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HX600
Axon 3003
CAS:
172705-89-4
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C29H30N2O2
- MW: 438.56
Description
HX600 is a synthetic agonist for RXR-Nurr1 heterodimer complex and prevents ischemia-induced neuronal damage.
More Information
| Parent CAS No. | 172705-89-4 |
|---|---|
| Chemical Name | (Z)-4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid |
| SMILES | C1C=C2N=C(C3C=CC(C(O)=O)=CC=3)C3C=C4C(C)(C)CCC(C)(C)C4=CC=3N(C)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C29H30N2O2/c1-28(2)14-15-29(3,4)22-17-25-20(16-21(22)28)26(18-10-12-19(13-11-18)27(32)33)30-23-8-6-7-9-24(23)31(25)5/h6-13,16-17H,14-15H2,1-5H3,(H,32,33) |
| InChiKey | DLFBCHSYAZBTSS-UHFFFAOYSA-N |
| CID | 128016 |
| Short Description | RXR-Nurr1 agonist |
References
- H Umemiya et al. Action mechanism of retinoid-synergistic dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5.
- N Hirasawa et al. Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3. Life Sci. 2001;68(11):1287-1294.
- S Loppi et al. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain Behav Immun. 2018;73:670-681.
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