Bulk Inquiry
DO264
Axon 2982
CAS:
2301866-59-9
Purity:
99%
- Soluble in DMSO
- MF: C23H20Cl2F3N5O2S
- MW: 558.4
Description
DO264 is a potent, selective, and in vivo active ABHD12 inhibitor with an IC50 value of 11 nM. DO264 augments inflammatory cytokine production from human THP-1 macrophage cells.
More Information
| Parent CAS No. | 2301866-59-9 |
|---|---|
| Chemical Name | 1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethoxy)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea |
| SMILES | C1N=CC(NC(=S)NC2CCN(C3N=CC=C(OC4C=CC(OC(F)(F)F)=CC=4Cl)C=3Cl)CC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H20Cl2F3N5O2S/c24-17-12-16(35-23(26,27)28)3-4-18(17)34-19-5-9-30-21(20(19)25)33-10-6-14(7-11-33)31-22(36)32-15-2-1-8-29-13-15/h1-5,8-9,12-14H,6-7,10-11H2,(H2,31,32,36) |
| InChiKey | PIEQDBPBBQPLPL-UHFFFAOYSA-N |
| CID | 134813646 |
| Short Description | ABHD12 inhibitor |
References
- D Ogasawara et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14(12):1099-1108.
- D Ogasawara et al. Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase a/ß-Hydrolase Domain-Containing 12 (ABHD12). J Med Chem. 2019 Feb 14;62(3):1643-1656.
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.