Fatostatin hydrobromide is a specific inhibitor of SREBP cleavage-activating protein (SCAP), which is required for SREBP activation. Fatostatin hydrobromide possesses antitumor properties including the inhibition of cancer cell proliferation, invasion, and migration, and it arrests cancer cells in G2/M phase. Fatostatin hydrobromide also inhibits tubulin polymerization, which perturbs mitotic spindle assembly and leads to mitotic catastrophe. Fatostatin hydrobromide has anticancer properties in cell culture and in vivo mouse models of prostate and brain cancers.

KEYWORDS: Fatostatin hydrobromide | supplier | SCAP inhibitor | Fatostatin A hydrobromide | 125B11 hydrobromide | CAS [298197-04-3] | [125256-00-0] | DNA-RNA | SREBP | Inhibitor | Transcription Factors