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Fatostatin hydrobromide
- Fatostatin A hydrobromide - 125B11 hydrobromide
Axon 2975
- Parent CAS: 125256-00-0
Purity:
99%
- Soluble in DMSO
- MF: C18H18N2S.HBr
- MW: 375.33
Description
Fatostatin hydrobromide is a specific inhibitor of SREBP cleavage-activating protein (SCAP), which is required for SREBP activation. Fatostatin hydrobromide possesses antitumor properties including the inhibition of cancer cell proliferation, invasion, and migration, and it arrests cancer cells in G2/M phase. Fatostatin hydrobromide also inhibits tubulin polymerization, which perturbs mitotic spindle assembly and leads to mitotic catastrophe. Fatostatin hydrobromide has anticancer properties in cell culture and in vivo mouse models of prostate and brain cancers.
More Information
| Parent CAS No. | 125256-00-0 |
|---|---|
| Chemical Name | 2-(2-Propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide |
| SMILES | C1(C2=CSC(C3C=C(CCC)N=CC=3)=N2)C=CC(C)=CC=1.Br |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H |
| InChiKey | RJCFNQZVFUMORB-UHFFFAOYSA-N |
| CID | 2850562 |
| Short Description | SCAP inhibitor |
References
- Y Choi et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28;278(9):7320-4.
- AA Gholkar et al. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. J Biol Chem. 2016 Aug 12;291(33):17001-8.
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